完整的和羧基末端甲状旁腺激素不会穿过血脑脊髓屏障。

Intact and carboxyterminal PTH do not cross the blood-cerebrospinal fluid barrier.

作者信息

Akmal M, Tuma S, Goldstein D A, Pattabhiraman R, Bernstein L, Massry S G

出版信息

Proc Soc Exp Biol Med. 1984 Sep;176(4):434-7. doi: 10.3181/00379727-176-41894.

Abstract

In order to examine whether parathyroid hormone (PTH) enters the cerebrospinal fluid (CSF), the blood levels of the hormone were acutely elevated either by infusion of parathyroid extract or by stimulation of the parathyroid glands by hypocalcemia. Despite marked elevations in the blood levels of the hormone, PTH could not be detected in the CSF. The data indicate the intact PTH or its carboxyterminal fragment do not cross the blood-CSF interface of the blood-brain barrier. The results, therefore, suggest that the action of PTH on brain must be mediated by an effect on the blood-brain interface of the blood-brain barrier.

摘要

为了检测甲状旁腺激素（PTH）是否进入脑脊液（CSF），通过输注甲状旁腺提取物或通过低钙血症刺激甲状旁腺来急性提高该激素的血液水平。尽管该激素的血液水平显著升高，但在脑脊液中未检测到PTH。数据表明完整的PTH或其羧基末端片段不会穿过血脑屏障的血-脑脊液界面。因此，结果提示PTH对大脑的作用必定是通过对血脑屏障的血脑界面产生影响来介导的。