单次大剂量甲基苯丙胺给药后大鼠脑尾状核中6-羟基多巴胺的形成。
Formation of 6-hydroxydopamine in caudate nucleus of the rat brain after a single large dose of methylamphetamine.
作者信息
Seiden L S, Vosmer G
出版信息
Pharmacol Biochem Behav. 1984 Jul;21(1):29-31. doi: 10.1016/0091-3057(84)90125-4.
PMID:6431452
Abstract
We now report that 6-hydroxydopamine (0.39 +/- 0.31 nanograms/mg of tissue at 2 hr) is formed in the rat caudate nucleus after a single injection of methylamphetamine (100 mg/kg). The same dose of methylamphetamine causes approximately 50% depletion of caudate dopamine 2 weeks after the injection. We suggest that the formation of 6-hydroxydopamine from endogenous dopamine is responsible for the neurotoxicity to dopamine terminals seen after methylamphetamine administration.
摘要
我们现在报告，单次注射甲基苯丙胺（100毫克/千克）后，大鼠尾状核中会形成6-羟基多巴胺（2小时时为0.39±0.31纳克/毫克组织）。相同剂量的甲基苯丙胺在注射后2周会导致尾状核多巴胺减少约50%。我们认为，内源性多巴胺形成6-羟基多巴胺是甲基苯丙胺给药后所见多巴胺终末神经毒性的原因。
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