Cuypers J, Cuevas A, Duisberg R
Neurochirurgia (Stuttg). 1978 Mar;21(2):62-6. doi: 10.1055/s-0028-1090323.
It was studied in rabbits whether indomethacin, a prostaglandin-synthesis inhibitor, influences cerebral hyperaemia induced by inhalation of carbon dioxide (CO2-response). The aim of this experiment was to show whether prostaglandins are involved in the regulation of cerebral vascular tone. The animals were repeatedly ventilated with a CO2-room air mixture before and after the injection of indomethacin solution. Regional cerebral blood flow in one hemisphere was continously measured using a thermo-clearance method. In 10 out of 13 rabbits no effect of indomethacin on the CO2 response could be observed. In the other 3 animals a reduction of the CO2-response only occurred in the 15-45 minutes interval after the indomethacin injection. The authors, however, do not exclude the possibility of this reduction being an artefact. The reasons are discussed.
在兔子身上研究了前列腺素合成抑制剂吲哚美辛是否会影响吸入二氧化碳引起的脑充血（二氧化碳反应）。本实验的目的是表明前列腺素是否参与脑血管张力的调节。在注射吲哚美辛溶液前后，用二氧化碳-室内空气混合物对动物进行反复通气。使用热清除法连续测量一个半球的局部脑血流量。在13只兔子中的10只中，未观察到吲哚美辛对二氧化碳反应有影响。在另外3只动物中，仅在注射吲哚美辛后的15至45分钟间隔内出现二氧化碳反应降低。然而，作者并不排除这种降低是一种假象的可能性。对原因进行了讨论。
