Shelton D W, Hendricks J D, Bailey G S
Toxicol Lett. 1984 Jul;22(1):27-31. doi: 10.1016/0378-4274(84)90041-9.
Rainbow trout (Salmo gairdneri) were fed diets containing 100 ppm Aroclor 1242 (AC42) or Aroclor 1254 (AC54) in combination with 1100 ppm diethylnitrosamine (DEN) for one year. The incidence of hepatocarcinomas was determined and compared with the incidence in trout fed 1100 ppm DEN alone. The two Aroclors dramatically enhanced tumor incidence from 10.2% in the positive controls (DEN alone) to 40.2% for AC42 and 21.6% for AC54. This is in contrast to previous results obtained when AC54 was fed concomitantly with aflatoxin B1 (AFB1), where a substantial inhibition of carcinogenesis was observed. The alteration of chemical carcinogenesis in trout by PCB, therefore, depends upon the carcinogen involved and is not a generalized effect.
虹鳟鱼（Salmo gairdneri）被喂食含有100 ppm多氯联苯混合物1242（AC42）或多氯联苯混合物1254（AC54）并搭配1100 ppm二乙基亚硝胺（DEN）的饲料，为期一年。测定了肝癌的发病率，并与仅喂食1100 ppm DEN的虹鳟鱼的发病率进行了比较。这两种多氯联苯混合物显著提高了肿瘤发病率，从阳性对照组（仅喂食DEN）的10.2%分别提高到AC42组的40.2%和AC54组的21.6%。这与之前将AC54与黄曲霉毒素B1（AFB1）同时喂食时获得的结果相反，当时观察到了对致癌作用的显著抑制。因此，多氯联苯对虹鳟鱼化学致癌作用的改变取决于所涉及的致癌物，并非普遍效应。
