Furst D E
Am J Med. 1984 Jul 13;77(1A):51-6. doi: 10.1016/s0002-9343(84)80019-4.
The clinical pharmacology of ibuprofen (Motrin, Upjohn) in relation to the pathophysiologic aspects of various diseases is explained. An understanding of prostaglandin's numerous effects can help the clinician to expand the use of ibuprofen (as in Barttern's syndrome) and to exercise caution as warranted, as when treating patients with renal disease. Knowledge of ibuprofen's clinical pharmacology may also enable practitioners to prescribe the drug rationally in situations not well represented in the literature, as in the elderly or in individuals with bleeding diatheses or severe liver disease. The use of ibuprofen in multiple-drug therapy with aspirin, warfarin, phenytoin, digoxin, or lithium is explored. Perusal of the literature enables the clinician to gain an awareness of patient subpopulations warranting careful use of medication, including the elderly or individuals with systemic lupus erythematosus, mixed connective tissue disease, or aspirin-induced asthma.
本文阐述了布洛芬（Motrin，Upjohn公司生产）的临床药理学及其与各种疾病病理生理方面的关系。了解前列腺素的多种作用有助于临床医生扩大布洛芬的应用范围（如在巴特综合征中），并在必要时谨慎用药，如治疗肾病患者时。掌握布洛芬的临床药理学知识还可能使从业者在文献中未充分体现的情况下合理开药，如老年患者或有出血倾向或严重肝病的个体。本文还探讨了布洛芬与阿司匹林、华法林、苯妥英钠、地高辛或锂盐联合用药的情况。研读文献能使临床医生认识到哪些患者亚群需要谨慎用药，包括老年人或患有系统性红斑狼疮、混合性结缔组织病或阿司匹林诱发哮喘的个体。
