Visca U, Giulivi A, Ventura M, Spina M, Massari A, Pomo A, Santi G
Boll Ist Sieroter Milan. 1984 May 31;63(2):154-9.
A decrease in the maturation process of monocytes into macrophage is observed in cancer patients. In this study the Authors examined: the maturation pattern of monocytes into macrophages in 14 patients of both sexes, between 45 and 70 years of age, with solid tumours of the lung, breast and gastrointestinal tract, without any infection; the variations induced on the maturation pattern as results of the administration of lithium carbonate. The results (evaluated statistically) show that in all patients there was a significant increase of monocytes-macrophages maturation from basal values, after 14 days of lithium carbonate treatment. Moreover, we also observed that 14 days after withdrawing of lithium carbonate, the values of monocytes-macrophages maturation return to their basal ones. The increase, as percentage of mean basal values, is higher in patients having low basal values of maturation.
在癌症患者中观察到单核细胞向巨噬细胞成熟过程的减少。在本研究中，作者检查了：14名年龄在45至70岁之间、患有肺癌、乳腺癌和胃肠道实体瘤且无任何感染的男女患者中单核细胞向巨噬细胞的成熟模式；碳酸锂给药对成熟模式产生的变化。结果（经统计学评估）显示，在所有患者中，碳酸锂治疗14天后，单核细胞 - 巨噬细胞的成熟度从基础值显著增加。此外，我们还观察到，停用碳酸锂14天后，单核细胞 - 巨噬细胞的成熟度值恢复到基础值。成熟度基础值较低的患者，其增加幅度（以平均基础值的百分比表示）更高。
