Rius E, Nadal C, Boffa G A
C R Acad Sci III. 1984;299(5):119-22.
A factor which inhibits the G1-S transition of synchronized proliferating hepatocytes is detected in human serum or plasma. This activity is associated with an electronegatively charged component of high molecular weight in the native serum. Serum and plasma submitted to trypsin hydrolysis or to liver microsomes, release an ultrafiltrable component of low molecular weight which displays the same activity as the high molecular weight one from the native serum. This inhibitory system of hepatocyte proliferation is similar to that already described in Rat serum. It is species independent.
在人血清或血浆中检测到一种抑制同步增殖肝细胞G1-S期转换的因子。该活性与天然血清中一种带负电荷的高分子量成分相关。经胰蛋白酶水解或肝微粒体处理的血清和血浆会释放出一种低分子量的可超滤成分，其表现出与天然血清中高分子量成分相同的活性。这种肝细胞增殖抑制系统与已在大鼠血清中描述的系统相似。它不依赖于物种。
