左炔诺孕酮与乙醇相互作用的研究。

A study of interaction between levonorgestrel and ethanol.

作者信息

Gomaa A A, Osman F H, Salem H T, Abdel Wareth A A

出版信息

Contraception. 1984 Jun;29(6):535-42. doi: 10.1016/s0010-7824(84)80015-3.

Abstract

Female Wistar rats were pair-fed a diet containing either ethanol (5%) or isocaloric carbohydrate substituent. After 6 weeks, a single dose (5 micrograms/kg) of levonorgestrel was given to the animals in each group either orally, subcutaneously or intravenously. Plasma levels of levonorgestrel at different time intervals were measured by RIA. Chronic alcohol administration did not affect plasma levels of levonorgestrel after oral administration. When the drug was given subcutaneously, plasma levels and AUC were significantly decreased in the alcoholic compared to control group. Following intravenous administration, the elimination half-life of levonorgestrel was shorter while the metabolic clearance was higher in the alcohol-treated group rather than the control group.

摘要

将雌性Wistar大鼠成对饲养，分别给予含乙醇（5%）或等热量碳水化合物替代物的饮食。6周后，给每组动物口服、皮下注射或静脉注射单剂量（5微克/千克）左炔诺孕酮。通过放射免疫分析法测定不同时间间隔的血浆左炔诺孕酮水平。长期给予酒精对口服左炔诺孕酮后的血浆水平没有影响。与对照组相比，皮下注射该药物时，酒精处理组的血浆水平和曲线下面积显著降低。静脉注射后，酒精处理组左炔诺孕酮的消除半衰期较短，而代谢清除率较高，对照组则相反。