Ohuchi K, Watanabe M, Levine L
Int Arch Allergy Appl Immunol. 1984;75(2):157-63. doi: 10.1159/000233607.
Two types of allergic air pouch inflammation, the acute and the chronic types, were induced in the dorsum of rats. 1, 8, and 24 h after the immunologic challenge injection, the exudate contents of cyclooxygenase products, prostaglandin (PG)E2, 13,14-dihydro-15-keto-PGE2, PGI2 (measured as 6-keto-PGF1 alpha) and PGD2, and the lipoxygenase products, hydroxyeicosatetraenoic acids (HETEs) and 6-sulfido-peptide-containing leukotrienes (SRS) were measured by radioimmunoassay. The effects of locally injected indomethacin or dexamethasone on the exudate volumes and the number of cells in the exudates in both types of allergic inflammation and the effects of these drugs on the contents of the cyclooxygenase and lipoxygenase products in the exudates 8 h after the challenge injection were examined.
在大鼠背部诱发了两种过敏性气囊炎症，即急性和慢性炎症。在免疫激发注射后1、8和24小时，通过放射免疫测定法测量了环氧化酶产物、前列腺素（PG）E2、13,14-二氢-15-酮-PGE2、PGI2（以6-酮-PGF1α测量）和PGD2的渗出物含量，以及脂氧合酶产物、羟基二十碳四烯酸（HETEs）和含6-硫肽的白三烯（SRS）。研究了局部注射吲哚美辛或地塞米松对两种过敏性炎症渗出物体积和渗出物中细胞数量的影响，以及这些药物对激发注射后8小时渗出物中环氧化酶和脂氧合酶产物含量的影响。
