Post R M, Berrettini W, Uhde T W, Kellner C
J Clin Psychopharmacol. 1984 Aug;4(4):178-85.
Acute and prophylactic effects of carbamazepine are documented in a double-blind clinical trial in a 55-year-old treatment-refractory, lithium-non-responsive, manic-depressive patient. Double-blind crossover to two other anticonvulsants was also achieved; the patient showed no evidence of response to phenytoin or valproic acid. The clinical and theoretical issues raised by the selective response to carbamazepine in this patient are discussed.
在一项针对一名55岁治疗难治性、锂盐无反应的双相情感障碍患者的双盲临床试验中，记录了卡马西平的急性和预防作用。还实现了对另外两种抗惊厥药物的双盲交叉试验；该患者对苯妥英或丙戊酸无反应迹象。讨论了该患者对卡马西平的选择性反应所引发的临床和理论问题。
