Carlson R P, Gilman S C, Hodge T G, O'Neill-Davis L, Blazek E M, Lewis A J
J Immunopharmacol. 1984;6(1-2):69-78. doi: 10.3109/08923978409026459.
We examined the effects of two prostaglandin synthetase inhibitors, aspirin and oxaprozin, on the development of lupus-like disease in MRL/1 mice. Daily oral administration of 100 mg/kg of these compounds over a period of 3 months significantly reduced thymic lymphoid hyperplasia. In addition, aspirin but not oxaprozin significantly lowered total lymphocyte counts in the peripheral blood. Other drug-related changes, including reduced hyperplasia in the spleen and lymph nodes and an improvement in kidney vasculitis by aspirin, did not reach statistical significance. Neither aspirin nor oxaprozin influenced the circulating levels of anti-ds DNA antibodies or the severity of kidney glomerulonephritis. While the overall effects of these cyclooxygenase inhibitors were not dramatic, the results do indicate that further studies are warranted to determine the precise therapeutic role, if any, for PG-synthetase inhibitors in lupus-like disease.
我们研究了两种前列腺素合成酶抑制剂——阿司匹林和恶丙嗪，对MRL/1小鼠狼疮样疾病发展的影响。在3个月的时间里，每日口服100 mg/kg这些化合物可显著减轻胸腺淋巴样增生。此外，阿司匹林可显著降低外周血中的总淋巴细胞计数，而恶丙嗪则无此作用。其他与药物相关的变化，包括阿司匹林使脾脏和淋巴结增生减少以及改善肾血管炎，但未达到统计学意义。阿司匹林和恶丙嗪均未影响抗双链DNA抗体的循环水平或肾小球肾炎的严重程度。虽然这些环氧化酶抑制剂的总体效果并不显著，但结果确实表明有必要进行进一步研究，以确定PG合成酶抑制剂在狼疮样疾病中是否具有确切的治疗作用（若有）。
