Tamai K, Nakao J, Nakagawa K, Watanabe K, Sakashita H, Nishiwaki Y, Nakashin T
Jpn J Exp Med. 1983 Oct;53(5):251-6.
Antitumor activity of Fusobacterium nucleatum strain KO-31, which had been isolated from the oral cavity, was investigated in Ehrlich carcinoma-bearing mice. The strain KO-31 was cultured in TF medium for 48 hr. One-half ml of the culture supernatant fluid was injected intraperitoneally during a 7-day period to mice with Ehrlich ascites carcinoma. The survival time of the treated mice prolonged remarkably. A significant reduction in size of the solid Ehrlich tumor was also achieved with the supernatant. Antitumor activity was not observed in the cell extract.
对从口腔分离出的具核梭杆菌KO - 31菌株在艾氏腹水癌荷瘤小鼠中的抗肿瘤活性进行了研究。将KO - 31菌株在TF培养基中培养48小时。在7天的时间内，向患有艾氏腹水癌的小鼠腹腔内注射0.5毫升培养上清液。经处理的小鼠存活时间显著延长。上清液还使艾氏实体瘤的大小显著减小。在细胞提取物中未观察到抗肿瘤活性。
