Nikolov R
Methods Find Exp Clin Pharmacol. 1984 May;6(5):231-4.
The anti-hypoxic effect of drugs that inhibit different steps of arachidonic acid metabolism was studied using an experimental model of acute hypobaric hypoxia in mice. The drugs investigated were chloroquine, betamethasone, chlorpromazine (phospholipase A2 inhibitors), ketoprofen (cyclo-oxygenase inhibitor) and imidazole (TxA2 synthetase inhibitor). Prostacyclin (PGI2) and PGF2 alpha were also studied. The results show that all the inhibitors of arachidonic acid metabolism manifest an anti-hypoxic effect of a various degree. PGF2 alpha had a deleterious effect, and PGI2 showed a marked anti-hypoxic effect. The results suggest that it is advantageous to search for anti-hypoxic drugs among the blockers of arachidonic acid cascade.
利用小鼠急性低压缺氧实验模型，研究了抑制花生四烯酸代谢不同步骤的药物的抗缺氧作用。所研究的药物有氯喹、倍他米松、氯丙嗪（磷脂酶A2抑制剂）、酮洛芬（环氧化酶抑制剂）和咪唑（血栓素A2合成酶抑制剂）。还研究了前列环素（PGI2）和前列腺素F2α。结果表明，所有花生四烯酸代谢抑制剂均表现出不同程度的抗缺氧作用。前列腺素F2α有有害作用，而前列环素表现出明显的抗缺氧作用。结果提示，在花生四烯酸级联反应阻断剂中寻找抗缺氧药物是有益的。
