Modnikov O P
Med Radiol (Mosk). 1984 Aug;29(8):14-6.
Radioimmunoassay of the hypothalamic-hypophyseal-ovarian interrelationships was performed in 87 patients with cervical cancer and 37 practically healthy women. The patients were examined before concomitant radiation therapy, after administration of the half dose to the focus, immediately after irradiation and 3-12 mos. and 2-5 yrs. after it. The basal level of the follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol as well as their response to the administration of the releasing factor of the hypothalamus (luliberin) were studied. Some disorders that manifested themselves in the decreased level of estradiol, were established in the patients with cervical cancer even before irradiation. Concomitant radiation therapy resulted in pronounced changes in the activities of the hypothalamic-hypophyseal-ovarian system that manifested themselves in the lowered rate of LH increment in response to the administration of luliberin and the absence of estradiol response to the load. These changes persisted long after the termination of concomitant radiation therapy.
对87例宫颈癌患者和37名实际健康的女性进行了下丘脑 - 垂体 - 卵巢相互关系的放射免疫测定。在同步放射治疗前、对病灶给予半量照射后、照射后即刻以及照射后3 - 12个月和2 - 5年对患者进行检查。研究了促卵泡激素（FSH）、促黄体生成素（LH）和雌二醇的基础水平及其对下丘脑释放因子（促黄体素释放激素）给药的反应。即使在照射前，宫颈癌患者就已出现一些表现为雌二醇水平降低的紊乱情况。同步放射治疗导致下丘脑 - 垂体 - 卵巢系统活动发生明显变化，表现为对促黄体素释放激素给药后LH增量率降低以及对负荷无雌二醇反应。这些变化在同步放射治疗结束后很长时间仍持续存在。
