一种改进的尿液中3-甲氧基-4-羟基扁桃酸排泄的筛查方法。
An improved screening method for 3-methoxy-4-hydroxy mandelic acid excretion in urine.
作者信息
Rumble B A, Dick M
出版信息
Pathology. 1978 Jan;10(1):53-7. doi: 10.3109/00313027809063479.
A screening method is described for urinary 3-methoxy-4-hydroxy mandelic acid using an initial ion exchange procedure, vanillin formation and extraction into toluene. The technique, is simple, rapid and specific, with a reference value up to 35 mumol (7.0 mg)/day established on 92 normal human subjects. Over 200 patients' urines were analysed by the method of which 18 gave values above the reference range. The majority of these increased excretions are attributed to the metabolic effects of drugs, one patient suffered from phaeochromocytoma and only 2 results remaining unexplained.
本文描述了一种用于检测尿中3-甲氧基-4-羟基扁桃酸的筛查方法，该方法采用初始离子交换程序、香草醛形成以及甲苯萃取。该技术简单、快速且具有特异性，在92名正常人类受试者中确定的参考值高达35微摩尔（7.0毫克）/天。通过该方法分析了200多名患者的尿液，其中18名患者的值高于参考范围。这些排泄增加大多归因于药物的代谢作用，一名患者患有嗜铬细胞瘤，只有2个结果仍无法解释。
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