Feuerstein G, Lozovsky D, Cohen L A, Labroo V M, Kirk K L, Kopin I J, Faden A I
Neuropeptides. 1984 Jun;4(4):303-10. doi: 10.1016/0143-4179(84)90004-0.
The effects of thyrotropin-releasing hormone (TRH) and the TRH-analogs, 4-fluoro-Im-TRH (4-F-TRH) and 2-trifluoromethyl-Im-TRH (2-TFM-TRH), on the cardiovascular system and prolactin (PRL) release were examined in conscious rats. TRH (2.8 or 28 nmol) injected into the anterior hypothalamus produced dose-dependent increments in blood pressure and heart rate; plasma PRL was increased twofold after the higher dose of TRH. 4-F-TRH had effects similar to those of TRH on both the cardiovascular and PRL response. In contrast, the 2-TFM-TRH was significantly less active than TRH or 4-F-TRH in eliciting tachycardia, yet was noticeably more potent in affecting PRL release. These data suggest that the receptors for TRH-induced PRL release may be different from TRH-receptors which mediate central cardiovascular responses.
在清醒大鼠中研究了促甲状腺激素释放激素（TRH）及其类似物4-氟-Im-TRH（4-F-TRH）和2-三氟甲基-Im-TRH（2-TFM-TRH）对心血管系统和催乳素（PRL）释放的影响。向下丘脑前部注射TRH（2.8或28 nmol）可使血压和心率呈剂量依赖性增加；较高剂量的TRH使血浆PRL增加两倍。4-F-TRH对心血管和PRL反应的影响与TRH相似。相比之下，2-TFM-TRH诱发心动过速的活性明显低于TRH或4-F-TRH，但在影响PRL释放方面的效力明显更强。这些数据表明，TRH诱导PRL释放的受体可能与介导中枢心血管反应的TRH受体不同。
