Roberts E
Neurosci Lett. 1984 Jun 29;47(3):195-200. doi: 10.1016/0304-3940(84)90513-5.
My current working models of nervous system function place particular emphasis on the roles of inhibitory GABAergic neurons in information processing in the central nervous system. It is proposed that in behavioral sequences, innate or learned, preprogrammed neural circuits are released to function at varying rates and in various combinations largely by disinhibition of pacemaker neurons whose activities are under the dual tonic inhibitory control of GABAergic local circuit neurons and projection command neurons. According to this view, disinhibition is permissive and excitatory input to pacemaker neurons has mainly a modulatory role. Disturbances in GABAergic function probably occur in a variety of neurologic and psychologic disorders.
我目前关于神经系统功能的工作模型特别强调抑制性γ-氨基丁酸能神经元在中枢神经系统信息处理中的作用。有人提出，在行为序列中，无论是先天的还是后天习得的，预先编程的神经回路在很大程度上是通过解除对起搏器神经元的抑制来以不同的速率和各种组合发挥作用的，这些起搏器神经元的活动受到γ-氨基丁酸能局部回路神经元和投射指令神经元的双重紧张性抑制控制。根据这一观点，去抑制是允许性的，对起搏器神经元的兴奋性输入主要起调节作用。γ-氨基丁酸能功能障碍可能发生在多种神经和心理疾病中。
