Regnier A, Bonnefoi M, Lescure F
Res Vet Sci. 1984 Jul;37(1):26-9.
Inhibitory effects of the anti-inflammatory agents lysine-acetylsalicylate (LAS) and phenylbutazone (PBZ) on the breakdown of the blood-aqueous barrier by paracentesis were studied in canine eyes using protein determination of ocular fluid. In the untreated eyes the aqueous protein value was raised from 0.29 +/- 0.17 (mean +/- SD) g litre-1 at the initial paracentesis to 14.47 +/- 4.10 g litre-1 at the second paracentesis. Pretreatment with LAS or PBZ had no significant effect on the protein concentration of the primary aqueous humour. However the secondary aqueous protein concentration was only 10.05 +/- 7.00 g litre-1 with LAS and 5.80 +/- 3.83 g litre-1 with PBZ. With both drugs the maximum inhibitory effect was observed on the gammaglobulins and albumin. These results suggest that prostaglandins may be involved in the response of the canine eye to paracentesis and that premedication with LAS or PBZ may be of value in reducing postoperative ocular inflammation.
利用眼内液蛋白质测定法，在犬眼上研究了抗炎药赖氨酸阿司匹林（LAS）和保泰松（PBZ）对穿刺引起的血-房水屏障破坏的抑制作用。在未经治疗的眼中，穿刺初期房水蛋白质值从0.29±0.17（均值±标准差）克/升升至第二次穿刺时的14.47±4.10克/升。LAS或PBZ预处理对原发性房水的蛋白质浓度无显著影响。然而，LAS处理后的继发性房水蛋白质浓度仅为10.05±7.00克/升，PBZ处理后的为5.80±3.83克/升。两种药物对γ球蛋白和白蛋白均观察到最大抑制作用。这些结果表明，前列腺素可能参与犬眼对穿刺的反应，且LAS或PBZ预处理可能对减轻术后眼部炎症有价值。
