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食管横断环的组织学因素作为静脉曲张出血发病机制的线索。

Histologic factors of the esophageal transection ring as clues to the pathogenesis of bleeding varices.

作者信息

Spence R A, Sloan J M, Johnston G W

出版信息

Surg Gynecol Obstet. 1984 Sep;159(3):253-9.

PMID:6433497
Abstract

In the absence of other precipitating factors, such as Sengstaken intubation, there is little evidence for acute esophagitis being a major factor in precipitating hemorrhage from varices. Superficial blood filled channels are described lying within the epithelium. They appear to arise from papillae, extend close to the esophageal lumen and are lined by epithelial-like cells. It is proposed that rupture of these channels may initiate variceal bleeding and, being connected to the underlying larger vessels, give rise to substantial hemorrhage. It is also suggested that these superficial vascular channels may correspond to the cherry red spots seen on endoscopic examination.

摘要

在没有其他诱发因素(如三腔二囊管插管)的情况下,几乎没有证据表明急性食管炎是导致静脉曲张出血的主要因素。上皮内可见充满血液的浅表通道。它们似乎起源于乳头,延伸至靠近食管腔的位置,内衬类似上皮的细胞。有人提出这些通道的破裂可能引发静脉曲张出血,并由于与下方较大血管相连而导致大量出血。也有人认为这些浅表血管通道可能与内镜检查时所见的樱桃红点相对应。

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Histologic factors of the esophageal transection ring as clues to the pathogenesis of bleeding varices.食管横断环的组织学因素作为静脉曲张出血发病机制的线索。
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Increased serum activity of matrix metalloproteinase-9 in patients with acute variceal bleeding.急性静脉曲张出血患者血清基质金属蛋白酶-9 活性升高。
Gut Liver. 2012 Apr;6(2):249-55. doi: 10.5009/gnl.2012.6.2.249. Epub 2012 Apr 17.
2
Anti-inflammatory drugs and variceal bleeding: a case-control study.抗炎药物与静脉曲张出血:一项病例对照研究。
Gut. 1999 Feb;44(2):270-3. doi: 10.1136/gut.44.2.270.
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Prophylaxis of first variceal hemorrhage in patients with liver cirrhosis.肝硬化患者首次静脉曲张出血的预防
Klin Wochenschr. 1986 Dec 15;64(24):1267-75. doi: 10.1007/BF01785707.
4
Pressure of intraoesophageal varices assessed by fine needle puncture: its relation to endoscopic signs and severity of liver disease in patients with cirrhosis.细针穿刺评估食管静脉曲张压力:其与肝硬化患者内镜表现及肝病严重程度的关系
Gut. 1989 Feb;30(2):228-32. doi: 10.1136/gut.30.2.228.
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Scanning electron microscopy of esophageal microvasculature in human infants and rabbits.人类婴儿和兔子食管微血管的扫描电子显微镜观察
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