Specificity of murine monoclonal antibodies induced by a choriocarcinoma cell-line (BEWO).

The specificity of two murine monoclonal antibodies (BW 252/104, IgG3 and BW 241/10, IgM) which recognize two different antigens is described. BW 252/104 recognizes an epitope detectable on all human cell lines and most of the human tissues tested. On account of this reactivity this antibody could be said to possess a "pan human" specificity. BW 241/10 is mainly reactive with human granulocytes but shows some binding to certain solid tissues (breast, stomach). Because of its lack of reactivity to human lymphocytes and monocytes this antibody could be of interest in the detection of human granulocytes.