Wattiaux-De Coninck S, Wattiaux R
Biochem Biophys Res Commun. 1984 Aug 30;123(1):286-90. doi: 10.1016/0006-291x(84)90410-8.
When injected into rats, a certain amount of mannitol is taken up by the liver and is associated with sedimentable structures. Isopycnic centrifugation in a sucrose gradient shows that a large part of mannitol is present in mitochondria, what remains is located in the lysosomes. The hypotonic release of mannitol present in organelles shows that the polyol is shared between mitochondria and lysosomes. The trapping of mannitol in lysosomes could result from the heterophagic or autophagic function of the lysosomes; the mechanism of its accumulation in mitochondria is still unexplained.
当将一定量的甘露醇注入大鼠体内时，肝脏会摄取一部分甘露醇，并与可沉降结构相关联。在蔗糖梯度中进行等密度离心显示，大部分甘露醇存在于线粒体中，其余的则位于溶酶体中。细胞器中甘露醇的低渗释放表明多元醇在线粒体和溶酶体之间共享。甘露醇在溶酶体中的截留可能是由于溶酶体的异噬或自噬功能；其在线粒体中积累的机制仍无法解释。
