Randall P K
Brain Res. 1984 Aug 13;308(2):333-6. doi: 10.1016/0006-8993(84)91073-4.
Lesion-induced dopaminergic supersensitivity was investigated in 4-, 10-, and 28-month-old C57BL/6J mice. Apomorphine-induced rotational behavior was examined 5, 10, and 20 days after destruction of the dopamine-containing nigro-striatal pathway by intrastriatal infusion of 6-OHDA. No major differences between ages were observed in the extent or rate of development of contralateral rotation. It is concluded that age-differences in dopaminergic supersensitization are dependent upon the nature and/or severity of the sensitizing stimulus.
在4个月、10个月和28个月大的C57BL/6J小鼠中研究了损伤诱导的多巴胺能超敏反应。通过纹状体内注射6-羟基多巴胺破坏含多巴胺的黑质-纹状体通路后5天、10天和20天，检测阿扑吗啡诱导的旋转行为。在对侧旋转的程度或发展速度上未观察到年龄之间的主要差异。得出的结论是，多巴胺能超敏反应的年龄差异取决于致敏刺激的性质和/或严重程度。
