Hasegawa J, Okada A, Nakao K, Kawashima Y
Cancer. 1984 Oct 15;54(8):1739-46. doi: 10.1002/1097-0142(19841015)54:8<1739::aid-cncr2820540845>3.0.co;2-j.
An experimental study was undertaken to evaluate the effects of total parenteral nutrition (TPN) on tumor growth in rats. Sato lung cancer was transplanted subcutaneously in male Donryu rats. Two weeks after inoculation, experimental animals were divided into three groups: Group I (5% G); Group II (21% G, 4% A.A; TPN) received intravenous infusion through cervical vein; Group III rats were maintained on a regular diet. All of the animals were killed on the eighth day. There was a significant increase in tumor volume and tumor weight in both G-II (7.3 +/- 3.9 cm3, 8.7 +/- 6.3 g) and G-III (7.4 +/- 4.6 cm3, 9.7 +/- 5.4 g), as compared with G-I (3.3 +/- 1.4 cm3, 3.7 +/- 1.9 g). In morphometric studies, an average area of tumor cell in G-II was 267 +/- 172 microns2, being significantly larger than in G-I (195 +/- 95 microns2) or G-III (185 +/- 93 microns2). The nuclear diameter of tumor cell was 9.9 +/- 2.2 microns in G-II, 9.2 +/- 1.9 micron in G-III, and 8.5 +/- 1.5 micron in G-I, respectively. Total water balance throughout the experimental period was +84.0 +/- 14.5 ml/100 g BW in G-II, +86.3 +/- 8.2 ml/100 g BW in G-III, and +44.8 +/- 22.5 ml/100 g body weight in G-I, respectively. Increased tumor volume and tumor weight found in G-II may not be due to hyperplasia of each tumor cell, but rather due possibly to water retention in tumor tissue.
进行了一项实验研究，以评估全胃肠外营养（TPN）对大鼠肿瘤生长的影响。将佐藤肺癌皮下移植到雄性东京大鼠体内。接种两周后，将实验动物分为三组：第一组（5%葡萄糖）；第二组（21%葡萄糖、4%氨基酸；TPN）通过颈静脉进行静脉输注；第三组大鼠维持常规饮食。所有动物均在第八天处死。与第一组（3.3±1.4立方厘米，3.7±1.9克）相比，第二组（7.3±3.9立方厘米，8.7±6.3克）和第三组（7.4±4.6立方厘米，9.7±5.4克）的肿瘤体积和肿瘤重量均显著增加。在形态计量学研究中，第二组肿瘤细胞的平均面积为267±172平方微米，明显大于第一组（195±95平方微米）或第三组（185±93平方微米）。第二组肿瘤细胞的核直径分别为9.9±2.2微米，第三组为9.2±1.9微米，第一组为8.5±1.5微米。在整个实验期间，第二组的总水平衡为+84.0±14.5毫升/100克体重，第三组为+86.3±8.2毫升/100克体重，第一组为+44.8±22.5毫升/100克体重。第二组中发现的肿瘤体积和肿瘤重量增加可能不是由于每个肿瘤细胞的增生，而是可能由于肿瘤组织中的水分潴留。
