Jackson C A, Greaves M, Boulton A J, Ward J D, Preston F E
Clin Sci (Lond). 1984 Nov;67(5):551-5. doi: 10.1042/cs0670551.
The effect of improved glycaemic control, effected by 16 weeks continuous subcutaneous insulin infusion (CSII), on platelet aggregation and platelet prostaglandin biosynthesis has been assessed in a group of 11 diabetic patients with painful peripheral neuropathy. Before CSII and compared with results obtained on samples from age- and sex-matched control subjects, there was enhanced reactivity of the platelets from diabetic patients to ADP, collagen and sodium arachidonate (NaAA). There was also increased thromboxane B2 (TXB2) production after platelet stimulation by NaAA. In contrast, collagen-induced thromboxane production by platelets from diabetic patients was significantly less than that of platelets from controls. Treatment by CSII resulted in a statistically significant improvement in glycaemic control and this was maintained for the 16 week period of the study. At 16 weeks and in the presence of near-normal glycaemic control, the enhanced platelet reactivity in response to collagen and NaAA persisted and that to ADP was further increased. Collagen-induced thromboxane production was, however, corrected by CSII.
在11例患有疼痛性周围神经病变的糖尿病患者中，评估了连续16周皮下胰岛素输注（CSII）改善血糖控制对血小板聚集和血小板前列腺素生物合成的影响。在进行CSII之前，与年龄和性别匹配的对照受试者样本的结果相比，糖尿病患者的血小板对ADP、胶原蛋白和花生四烯酸钠（NaAA）的反应性增强。在NaAA刺激血小板后，血栓素B2（TXB2）的产生也增加。相比之下，糖尿病患者血小板由胶原蛋白诱导的血栓素产生明显少于对照组血小板。CSII治疗使血糖控制有统计学意义的改善，并且在研究的16周期间得以维持。在16周时，在血糖接近正常的情况下，血小板对胶原蛋白和NaAA的反应性增强仍然存在，对ADP的反应性进一步增加。然而，CSII纠正了胶原蛋白诱导的血栓素产生。
