[系统性轻链病作为浆细胞瘤的一种并发症]
[Systemic light-chain disease as a complication of plasmacytoma].
作者信息
Grussendorf M, Grussendorf M, Waldherr R, Seelig H P, Ritz E
出版信息
Dtsch Med Wochenschr. 1984 Sep 14;109(37):1405-9. doi: 10.1055/s-2008-1069386.
An asymptomatic multiple myeloma of the kappa-light chain type was found in a patient with nephrotic syndrome and renal insufficiency. Light microscopy showed nodular glomerulosclerosis of the kidney similar to diabetic glomerulosclerosis. Diabetes mellitus could not be demonstrated. kappa-Light chain deposits could be shown by immunohistology in the mesangium and the glomerular and tubular basal membrane. In addition, massive kappa-light chain deposits in the sinusoidal walls of the liver and at the dermoepidermal junction of the skin and in the corium were found.
在一名患有肾病综合征和肾功能不全的患者中发现了κ轻链型无症状多发性骨髓瘤。光镜检查显示肾脏有结节性肾小球硬化，类似于糖尿病性肾小球硬化。未证实患有糖尿病。免疫组织学检查显示κ轻链沉积于系膜、肾小球和肾小管基底膜。此外，还发现肝脏窦壁、皮肤真皮表皮交界处和真皮中有大量κ轻链沉积。
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