19-去甲皮质酮和19-去甲孕酮在蟾蜍膀胱中的盐皮质激素活性

Mineralocorticoid activity of 19-nor-corticosterone and 19-nor-progesterone in the toad bladder.

作者信息

Schiff M J, Schwartz J H, Bengele H H, Dale S L, Melby J C, Alexander E A

出版信息

Endocrinology. 1984 Oct;115(4):1235-8. doi: 10.1210/endo-115-4-1235.

Abstract

19-Nor-corticosteroids are potentially important mineralocorticoids and hypertensive agents. We tested the mineralocorticoid potency of 19-nor-progesterone (19-NOR-P) and 19-nor-corticosterone (19-NOR-B) compared with aldosterone using the toad bladder short-circuit current as a measure of sodium transport. 19-NOR-B (10(-7) M) increased sodium transport to a degree not different from that caused by aldosterone (10(-7) M). The onset of action and duration of activity also were not different from those of aldosterone. 19-NOR-P (10(-7) M), however, had no effect on sodium transport. We conclude that 19-NOR-B has significant mineralocorticoid activity, while under the conditions of these studies, 19-NOR-P exhibited no effect on sodium transport.

摘要

19-去甲皮质类固醇是潜在重要的盐皮质激素和高血压因子。我们以蟾蜍膀胱短路电流作为钠转运的指标，比较了19-去甲孕酮（19-NOR-P）和19-去甲皮质酮（19-NOR-B）与醛固酮的盐皮质激素效力。19-NOR-B（10⁻⁷M）使钠转运增加的程度与醛固酮（10⁻⁷M）引起的程度无差异。其作用起效时间和活性持续时间也与醛固酮无异。然而，19-NOR-P（10⁻⁷M）对钠转运无影响。我们得出结论，19-NOR-B具有显著的盐皮质激素活性，而在这些研究条件下，19-NOR-P对钠转运无作用。