碳酸酐酶抑制作用对脑脊液与血液之间直流电位差的影响。

Effect of carbonic anhydrase inhibition on the DC potential difference between cerebrospinal fluid and blood.

作者信息

Davies D G, Britton S L, Gurtner G H, Dutton R E, Krasney J A

出版信息

Exp Neurol. 1984 Oct;86(1):66-72. doi: 10.1016/0014-4886(84)90067-0.

Abstract

The effect of cerebral carbonic anhydrase inhibition on the DC potential difference between cerebrospinal fluid (CSF) and blood (PD) was studied in anesthetized dogs by perfusing the ventriculocisternal system with artificial CSF containing the carbonic anhydrase inhibitor, acetazolamide. The slope of the PD vs. arterial blood pH (delta PD/delta pHa) was calculated from PD and pHa values obtained during room-air breathing, respiratory acidosis, and respiratory alkalosis. delta PD/delta pHa decreased from -26.3 +/- 1.9 millivolts per pH unit (mV/U) before acetazolamide administration to 17.6 +/- 2.1 after acetazolamide (P less than 0.02). The PD at pH 7.4 (PD7.4) increased slightly from 2.9 +/- 0.5 mV before acetazolamide treatment to 3.9 +/- 0.6 after acetazolamide (P less than 0.02). The results suggest that carbonic anhydrase could be involved in generating the PD between CSF and blood.

摘要

通过向脑室池系统灌注含碳酸酐酶抑制剂乙酰唑胺的人工脑脊液，研究了脑碳酸酐酶抑制对麻醉犬脑脊液（CSF）与血液之间直流电位差（PD）的影响。根据在常氧呼吸、呼吸性酸中毒和呼吸性碱中毒期间获得的PD和动脉血pH值（pHa）计算PD与动脉血pH的斜率（δPD/δpHa）。δPD/δpHa在给予乙酰唑胺前为-26.3±1.9毫伏/每pH单位（mV/U），给予后降至17.6±2.1（P<0.02）。pH 7.4时的PD（PD7.4）在给予乙酰唑胺前为2.9±0.5 mV，给予后略有升高至3.9±0.6（P<0.02）。结果表明碳酸酐酶可能参与脑脊液与血液之间PD的产生。