Feagin F F
J Oral Pathol. 1984 Oct;13(5):497-504. doi: 10.1111/j.1600-0714.1984.tb01450.x.
Gels of crude gelatin were dialyzed to eliminate fluoride, and then acidified with 75 mM lactic and 25 mM acetic acid at pH 4.2 and interfaced with enamel and root surfaces in gel-surface ratio of 0.2 ml/0.15 cm2. Enamel and root surface to gel mineral flux was reduced by initial inclusion of 0.5 and 1.0 mM fluoride with 2.5 mM calcium and 1.5 mM phosphate in gels at pH 4.2. Inclusion of 0.25 mM fluoride in the gels without added mineral ions had no effect in the first 22-day interface. The 0.25, 0.5 and 1.0 mM fluoride remarkably increased remineralization in a second 12-day interface. This indicated that the first fluoride exposure initiated formation of fluorapatites in the enamel which required a lower degree of gel saturation for enhanced remineralization in the second acid exposure. Fluoride had the same effect, but greater effectiveness on enamel than root-surface remineralization. Gels of crude gelatin may contain sufficient mineral ions to alter remineralization-demineralization of enamel and root surface.
将粗制明胶凝胶进行透析以去除氟化物，然后用75 mM乳酸和25 mM乙酸在pH 4.2条件下酸化，并以0.2 ml/0.15 cm²的凝胶-表面比例与牙釉质和牙根表面接触。在pH 4.2的凝胶中最初加入0.5和1.0 mM氟化物以及2.5 mM钙和1.5 mM磷酸盐，可降低牙釉质和牙根表面到凝胶的矿物质通量。在不添加矿物质离子的凝胶中加入0.25 mM氟化物，在最初的22天界面中没有影响。在第二个12天界面中，0.25、0.5和1.0 mM氟化物显著增加了再矿化。这表明首次接触氟化物引发了牙釉质中氟磷灰石的形成，在第二次酸暴露中增强再矿化需要较低程度的凝胶饱和度。氟化物有相同的效果，但对牙釉质再矿化的效果比对牙根表面再矿化的效果更好。粗制明胶凝胶可能含有足够的矿物质离子来改变牙釉质和牙根表面的再矿化-脱矿化过程。
