氟化物对大鼠胃黏膜的影响。

The effects of fluoride on the gastric mucosa of the rat.

作者信息

Pashley D H, Allison N B, Easmann R P, McKinney R V, Horner J A, Whitford G M

出版信息

J Oral Pathol. 1984 Oct;13(5):535-45. doi: 10.1111/j.1600-0714.1984.tb01454.x.

DOI:10.1111/j.1600-0714.1984.tb01454.x

Abstract

Fluoride is widely used for the prevention of dental caries. Very low concentrations of fluoride are routinely ingested in optimally fluoridated drinking water of many communities. Higher concentrations of fluoride in toothpastes, mouthrinses and topically applied gels also may be ingested, especially by children. The potential effect of ingested fluoride on the gastric mucosa was the subject of this investigation. Solutions of 0, 1, or 10 mM NaF in 0.1 N HCl were placed in rat stomachs in vivo for up to one hour. The effects of fluoride on the structure and function of the gastric mucosa were determined. Histologic and SEM examinations revealed dose- and time-dependent damage to the surface mucous cells. The 10 mM, but not the 1 mM, NaF solution increased gastric mucosal permeability to small but not to large molecules.

摘要

氟化物被广泛用于预防龋齿。许多社区的最佳氟化饮用水中通常含有极低浓度的氟化物。牙膏、漱口水和局部应用凝胶中较高浓度的氟化物也可能被摄入，尤其是儿童。本研究的主题是摄入氟化物对胃黏膜的潜在影响。将0、1或10 mM氟化钠在0.1 N盐酸中的溶液在大鼠体内置于胃中长达一小时。测定了氟化物对胃黏膜结构和功能的影响。组织学和扫描电镜检查显示表面黏液细胞存在剂量和时间依赖性损伤。10 mM的氟化钠溶液（而非1 mM的）增加了胃黏膜对小分子而非大分子的通透性。