Orko R, Heino A, Rosenberg P H, Alanen T
Acta Anaesthesiol Scand. 1984 Aug;28(4):452-6. doi: 10.1111/j.1399-6576.1984.tb02097.x.
Different initial doses of tubocurarine (0.1, 0.2, 0.3 and 0.4 mg kg-1) were given to 20 patients with and 20 patients without renal failure (RF) during standard anaesthesia. Neuromuscular blockade was registered with a device based on electromyography. A fluorescent technique was used to measure plasma tubocurarine concentrations, for which blood samples were drawn during induction and at reversal of neuromuscular block. The dose-response curves for the induction period were slightly steeper in patients with RF. A linear correlation between tubocurarine concentration and twitch response was found in both groups, although the curve had shifted to the left in RF patients. The total amount of tubocurarine used for surgical relaxation was lower in the RF than in the non-RF patients.
在标准麻醉期间，给20例有肾衰竭（RF）的患者和20例无肾衰竭的患者给予不同初始剂量的筒箭毒碱（0.1、0.2、0.3和0.4毫克/千克）。使用基于肌电图的设备记录神经肌肉阻滞情况。采用荧光技术测量血浆筒箭毒碱浓度，在诱导期和神经肌肉阻滞逆转时采集血样。RF患者诱导期的剂量-反应曲线稍陡。两组均发现筒箭毒碱浓度与抽搐反应之间呈线性相关，尽管RF患者的曲线已向左移动。用于手术松弛的筒箭毒碱总量，RF患者低于非RF患者。
