Kelly T M, Edwards C Q, Meikle A W, Kushner J P
Ann Intern Med. 1984 Nov;101(5):629-32. doi: 10.7326/0003-4819-101-5-629.
Gonadal function was evaluated in 64 persons homozygous for the HLA-linked hemochromatosis allele. Of 41 men, 10 had reduced libido or impotence and 6 had testicular atrophy. Before treatment, 5 men had below normal testosterone concentrations, 4 of whom also had low gonadotrophin levels. Four hypogonadal men were reevaluated after iron depletion treatment. In 2, 1 with primary and another with secondary hypogonadism, testosterone levels returned to normal after phlebotomy and were accompanied by a return of normal sexual function. None of 23 women with hemochromatosis had loss of libido or had a natural menopause before age 45. Our findings indicate that in some men with hereditary hemochromatosis and hypogonadism of either testicular or central origin, sexual function and sex hormone concentrations can be restored to normal after iron depletion therapy.
对64名HLA连锁血色素沉着病等位基因纯合子患者的性腺功能进行了评估。在41名男性中，10人性欲减退或阳痿，6人睾丸萎缩。治疗前，5名男性睾酮浓度低于正常水平，其中4人促性腺激素水平也较低。4名性腺功能减退的男性在进行铁耗竭治疗后接受了重新评估。在2名患者中，1名原发性性腺功能减退患者和另1名继发性性腺功能减退患者，放血治疗后睾酮水平恢复正常，同时性功能也恢复正常。23名血色素沉着病女性中，无一例性欲减退或在45岁前自然绝经。我们的研究结果表明，对于一些遗传性血色素沉着病且伴有睾丸或中枢性性腺功能减退的男性，铁耗竭治疗后性功能和性激素浓度可恢复正常。
