新型脑活性药物菲哌酯给药后的垂体分泌
Pituitary secretion after administration of a new cerebroactive drug, fipexide.
作者信息
Rolandi E, Franceschini R, Marabini A, Messina V, Bongera P, Barreca T
出版信息
Br J Clin Pharmacol. 1984 Aug;18(2):236-9. doi: 10.1111/j.1365-2125.1984.tb02460.x.
Abstract
The effect of a single oral dose of 400 mg fipexide on pituitary secretion was investigated in 10 elderly non-endocrine patients. Fipexide induced significant decrease (P less than 0.05) in serum prolactin (PRL) values at 90 and 120 min after drug administration, without affecting serum growth hormone (GH), gonadotropin (LH and FSH), thyrotropin (TSH) and cortisol values. Fipexide was unable to modify metoclopramide-induced PRL release in five of these patients. Our results show that this drug acts as a mild dopamine (DA) agonist, probably not directly affecting hypothalamic and/or pituitary DA receptors but indirectly via a reduced DA re-uptake at the pre-synaptic level.
摘要
在10名老年非内分泌患者中研究了单次口服400毫克菲哌酯对垂体分泌的影响。给药后90分钟和120分钟时，菲哌酯使血清催乳素（PRL）值显著降低（P<0.05），而不影响血清生长激素（GH）、促性腺激素（LH和FSH）、促甲状腺激素（TSH）和皮质醇值。在其中5名患者中，菲哌酯无法改变甲氧氯普胺诱导的PRL释放。我们的结果表明，该药物作为一种轻度多巴胺（DA）激动剂，可能不是直接影响下丘脑和/或垂体DA受体，而是通过减少突触前水平的DA再摄取间接起作用。
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J Clin Endocrinol Metab. 1980 Jun;50(6):994-8. doi: 10.1210/jcem-50-6-994.
2
[Fipexide: a new drug for the regulation of dopaminergic system at the macromolecular level].[菲派西德：一种在大分子水平调节多巴胺能系统的新药]
Boll Chim Farm. 1983 Feb;122(2):79-85.
3
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Acta Endocrinol (Copenh). 1980 Feb;93(2):139-48. doi: 10.1530/acta.0.0930139.
4
Radioimmunoassay for human follicle-stimulating hormone.人促卵泡激素的放射免疫测定法
J Clin Endocrinol Metab. 1967 Feb;27(2):295-9. doi: 10.1210/jcem-27-2-295.
5
Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone.放射免疫测定法：一种用于检测人绒毛膜促性腺激素和人促黄体生成素的方法。
Endocrinology. 1966 Jul;79(1):10-8. doi: 10.1210/endo-79-1-10.
6
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J Nucl Biol Med. 1969 Jan-Jun;13(1):26-36.
7
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9
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