Geerts M L, Hamers J, Schwarze E W, Kint A, Roels H, Lennert K
Cancer. 1984 Nov 15;54(10):2294-9. doi: 10.1002/1097-0142(19841115)54:10<2294::aid-cncr2820541040>3.0.co;2-m.
The simultaneous occurrence of two different lymphomas in a 57-year-old white woman is reported: mycosis fungoides and a leukemic lymphoplasmacytoid immunocytoma. The first was confirmed by histologic study and electron microscopy, and the latter by histologic study and immunoperoxidase staining. The lymphoid cells in the involved bone marrow and peripheral blood expressed the same surface immunoglobulin as was found in the cytoplasm of the immunocytoma cells, i.e., IgM-lambda. The clonal B-cell expansion was brought into a lasting remission by chlorambucil, but the cutaneous lymphoma proved to be refractory to therapy. The patient died 38 months after diagnosis.
报告了一名57岁白人女性同时发生两种不同淋巴瘤的病例：蕈样霉菌病和白血病性淋巴浆细胞样免疫细胞瘤。前者经组织学研究和电子显微镜检查确诊，后者经组织学研究和免疫过氧化物酶染色确诊。受累骨髓和外周血中的淋巴细胞表达了与免疫细胞瘤细胞胞质中相同的表面免疫球蛋白，即IgM-λ。苯丁酸氮芥使克隆性B细胞扩增得到持久缓解，但皮肤淋巴瘤对治疗耐药。患者在诊断后38个月死亡。
