Apolipoproteins of human plasma high density lipoproteins. Biology, biochemistry and clinical significance.

The steps involved in assembly, secretion and intravascular remodeling of plasma high density lipoproteins (HDL) are still largely unknown. However, recent progress has been made in understanding the biosynthesis of the major HDL-apolipoproteins, apo A-I and apo A-II. Combined with information about apoprotein gene structure, it has been possible to identify molecular lesion(s) associated with some clinical disorders of lipoprotein metabolism.