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[通过记录伴随负变化进行充分刺激的客观味觉测量]

[Objective gustometry with adequate stimulation by registration of contingent negative variation].

作者信息

Gerull G, Mrowinski D, Schilling V

出版信息

EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. 1984 Sep;15(3):121-6.

PMID:6435993
Abstract

Cortical evoked potentials require a steep and temporally reproduceable onset of sensory stimulation. As both items are difficult with gustatory stimuli, we tried to record the slow expectancy potential or "contingent negative variation" (CNV), which has turned out to be useful in objective olfactometry and speech audiometry. Sour, sweet, bitter or salty fluids were embedded in a water stream, which was sucked through a device well fitting to the tongue with holes at adequate locations. The negative vertex potential developped reproduceably between the recognition of taste and the acoustic signal, which could be expected only after one of the two alternatively offered gustatory stimuli. Clinical use of the method is demonstrated in a case of asymmetric loss of smell due to interruption of the chorda tympani during cholesteatoma operation. The CNV appeared only when stimulating the side of the tongue opposite to the ear operated on. In addition to the total or unilateral loss of taste, the ability to differentiate between two gustatory qualities can be diagnosed with an objective method, provided the patient cooperates by calm and attentive behaviour.

摘要

皮层诱发电位需要感觉刺激有陡峭且在时间上可重复的起始。由于这两点对于味觉刺激都很困难,我们尝试记录缓慢预期电位或“伴随负变化”(CNV),事实证明它在客观嗅觉测量和言语听力测定中很有用。酸味、甜味、苦味或咸味液体被嵌入水流中,水流通过一个与舌头适配且在适当位置有孔的装置被吸出。负顶电位在味觉识别和声学信号之间可重复地产生,而声学信号只有在两种交替提供的味觉刺激之一之后才会出现。该方法的临床应用在一例胆脂瘤手术中鼓索神经中断导致嗅觉不对称丧失的病例中得到了证明。只有在刺激与手术耳朵相对的舌侧时,CNV才会出现。除了味觉完全丧失或单侧丧失外,只要患者通过平静和专注的行为配合,就可以用一种客观方法诊断区分两种味觉性质的能力。

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