Al-Ansari A A, Khalil T H, Kelani Y, Mortimer C H
Fertil Steril. 1984 Oct;42(4):618-26. doi: 10.1016/s0015-0282(16)48148-3.
Two men with primary infertility after 6 to 11 years of marriage were found to have isolated follicle-stimulating hormone deficiency syndrome (IFDS). Their endogenous gonadotropin secretion was compared with that of two other infertile men with hypothalamic disease (Kallmann's syndrome) and pituitary tumor with hyperprolactinemia. Treatment with intramuscular gonadotropin was given to produce circulating and 24-hour urine levels of luteinizing hormone and follicle-stimulating hormone at or above the upper limit of the normal male range to ensure continued gonadal stimulation. Sperm counts increased in IFDS men within 6 to 26 weeks, with maximum total sperm counts of 33.5 and 20 million after 9 to 80 weeks. Pregnancy occurred after 20 weeks' therapy in one patient's wife with the subsequent delivery of a normal male infant. IFDS may be a treatable cause of male infertility given adequate gonadotropin therapy.
两名结婚6至11年后患有原发性不育症的男性被发现患有孤立性促卵泡激素缺乏综合征（IFDS）。将他们的内源性促性腺激素分泌情况与另外两名患有下丘脑疾病（卡尔曼综合征）和伴有高泌乳素血症的垂体瘤的不育男性进行了比较。给予肌肉注射促性腺激素治疗，以使黄体生成素和促卵泡激素的循环水平及24小时尿水平达到或高于正常男性范围的上限，以确保持续的性腺刺激。IFDS男性的精子计数在6至26周内增加，9至80周后最大总精子计数分别为3350万和2000万。一名患者的妻子在接受20周治疗后怀孕，随后产下一名正常男婴。给予足够的促性腺激素治疗后，IFDS可能是男性不育症的一个可治疗病因。
