Kubota T, Yaoi Y, Nagae M, Kumasaka T, Saito M
Fertil Steril. 1984 Nov;42(5):724-9.
The purpose of this study was to investigate the prolactin (PRL)-releasing mechanism of the hypothalamo-pituitary axis in pregnancy. Forty-six gravidas in the first and second trimesters received bromocriptine (BRC), 2.5 mg orally, metoclopramide (MCP), 10 mg intravenously, or thyrotropin-releasing hormone (TRH), 500 micrograms intravenously. Additionally, BRC was given orally to another 42 gravidas 60 minutes prior to the intravenous injection of MCP or TRH. The plasma PRL levels decreased significantly after BRC and remained significantly elevated after MCP or TRH administration. However, there were no significant differences of PRL response to these agents between the first- and second-trimester groups. The PRL release from the pituitary by MCP or TRH was suppressed significantly by pretreatment of BRC in the gravidas. We concluded that the control mechanism of PRL secretion remained unchanged in the first and second trimesters.
本研究的目的是探讨孕期下丘脑 - 垂体轴的催乳素（PRL）释放机制。46名孕早期和孕中期的孕妇口服2.5mg溴隐亭（BRC）、静脉注射10mg甲氧氯普胺（MCP）或静脉注射500μg促甲状腺激素释放激素（TRH）。此外，在静脉注射MCP或TRH前60分钟，给另外42名孕妇口服BRC。BRC给药后血浆PRL水平显著下降，MCP或TRH给药后血浆PRL水平仍显著升高。然而，孕早期组和孕中期组对这些药物的PRL反应无显著差异。BRC预处理可显著抑制孕妇中MCP或TRH引起的垂体PRL释放。我们得出结论，孕早期和孕中期PRL分泌的控制机制保持不变。
