Butenandt O
Fortschr Med. 1984 Sep 13;102(34):838-40.
A deficiency in growth hormone depresses growth and leads to dwarfism. The cause of hypopituitarism may be the destruction of the hypothalamus by a tumor infection or trauma. Birth trauma is often the underlying cause. Genetic forms or cerebral defects have also been described. Growth hormone may be completely lacking or partially reduced. Neurohormonal dysfunction is of particular interest. Administration, either intramuscular or subcutaneously, of human growth hormone leads initially to "catch-up" growth and to subsequent normal growth. Early treatment should be instituted if normal adult height is to be achieved.
生长激素缺乏会抑制生长并导致侏儒症。垂体功能减退的原因可能是肿瘤、感染或创伤对下丘脑的破坏。产伤往往是根本原因。也有关于遗传形式或脑缺陷的描述。生长激素可能完全缺乏或部分减少。神经激素功能障碍尤其值得关注。通过肌肉注射或皮下注射给予人生长激素，最初会导致“追赶性”生长，随后实现正常生长。如果要达到正常成人身高，应尽早开始治疗。
