Yesudian P, Premalatha S, Thambiah A S
Int J Dermatol. 1984 Sep;23(7):468-71. doi: 10.1111/ijd.1984.23.7.468.
Multiple melanotic macules of varying sizes were present on the palmar surfaces of 42 of 50 consecutive South Indian patients with von Recklinghausen's disease. The histologic characteristics of the macules showed localized areas of fingerlike prolongations of the rete ridges with increased pigmentation of the basal cells. This epidermal change overlies a small neurofibroma accompanied by thick-walled blood vessels in the reticular dermis. A clinicopathologic correlation of these palmar melanotic macules constitutes yet another frequent and specific marker of classical neurofibromatosis.
在50例连续的患有冯·雷克林霍增氏病的南印度患者中，42例患者的手掌表面出现了大小各异的多个黑素沉着斑。这些斑的组织学特征显示， rete嵴呈指状局部延长，基底细胞色素沉着增加。这种表皮变化覆盖在一个小神经纤维瘤上，网状真皮层伴有厚壁血管。这些手掌黑素沉着斑的临床病理相关性构成了经典神经纤维瘤病的又一个常见且特异的标志。
