Pilepich M V, Walz B J, Baglan R J
Int J Radiat Oncol Biol Phys. 1984 Oct;10(10):1869-73. doi: 10.1016/0360-3016(84)90264-5.
Twenty-eight patients received postoperative radiotherapy with curative intent following either radical prostatectomy (18 patients) or enucleative prostatectomy (10 patients). In patients undergoing radical prostatectomy, the indications for postoperative radiotherapy included positive margins in 13, "close" margins in 2, and seminal vesicle involvement in 3 patients. The majority of patients (82%) received total dose to the prostatic bed in excess of 6500 rad. In over 80% of the patients, the pelvic lymphatics are also treated (to a total dose of 4000-5000 rad). Minimum follow-up is one year, maximum is 10 years, average 54 months, median 41 months. Local recurrence was observed in only 1 patient, who was treated post-enucleation. All of the patients irradiated after radical prostatectomy clinically remained disease-free locally. Approximately one-half of the patients in both the enucleation and radial prostatectomy groups developed evidence of distant metastases. The complications of treatment have been comparable to those in patients treated with radiotherapy only. The continence status has not been affected significantly. All patients (5 in the radical prostatectomy group and 2 in the enucleation group) with incontinence following completion of radiotherapy had documented impairment of continence prior to radiotherapy. Postoperative radiotherapy administered following either radical or enucleative prostatectomy was tolerated well and resulted in excellent local control.
28例患者在根治性前列腺切除术（18例）或前列腺剜除术后（10例）接受了根治性术后放疗。在接受根治性前列腺切除术的患者中，术后放疗的指征包括13例切缘阳性、2例“切缘接近”以及3例精囊受累。大多数患者（82%）前列腺床的总剂量超过6500拉德。超过80%的患者还接受了盆腔淋巴引流区放疗（总剂量4000 - 5000拉德）。最短随访时间为1年，最长为10年，平均54个月，中位数41个月。仅1例前列腺剜除术后接受放疗的患者出现局部复发。所有根治性前列腺切除术后接受放疗的患者临床上局部均无疾病。前列腺剜除术组和根治性前列腺切除术组中约一半的患者出现远处转移迹象。治疗并发症与单纯放疗患者相当。控尿状态未受到明显影响。放疗结束后出现尿失禁的所有患者（根治性前列腺切除术组5例，前列腺剜除术组2例）在放疗前均有尿失禁记录。根治性或剜除性前列腺切除术后进行的术后放疗耐受性良好，局部控制效果极佳。
