用[18F]氟气进行芳香族放射性氟化反应：6-[18F]氟-L-多巴。
Aromatic radiofluorination with [18F]fluorine gas: 6-[18F]fluoro-L-dopa.
作者信息
Firnau G, Chirakal R, Garnett E S
出版信息
J Nucl Med. 1984 Nov;25(11):1228-33.
PMID:6436449
Abstract
A new synthesis is described for the routine production of 3,4-dihydroxy-6-[18F]fluoro-phenyl-L-alanine (6-[18F]fluoro-L-dopa). The reaction between [18F]fluorine gas and 3,4-dihydroxyphenyl-L-alanine (L-dopa) in liquid hydrogen fluoride gave 2-, 5-, and 6-[18F]fluoro-L-dopa. 6-[18F]Fluoro-L-dopa was isolated by reverse-phase high-pressure liquid chromatography. From 100 mCi [18F]F2, the method produces 3 mCi of 6-[18F]fluoro-L-dopa at the end of synthesis.
摘要
描述了一种用于常规生产3,4-二羟基-6-[¹⁸F]氟代苯基-L-丙氨酸（6-[¹⁸F]氟-L-多巴）的新合成方法。在液态氟化氢中，[¹⁸F]氟气与3,4-二羟基苯基-L-丙氨酸（L-多巴）反应生成2-、5-和6-[¹⁸F]氟-L-多巴。通过反相高压液相色谱法分离出6-[¹⁸F]氟-L-多巴。从100毫居里的[¹⁸F]F₂开始，该方法在合成结束时可产生3毫居里的6-[¹⁸F]氟-L-多巴。
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