Gupta P C, Rapin I, Houroupian D S, Roy S, Llena J F, Tandon P N
Neuropediatrics. 1984 Oct;15(4):191-7. doi: 10.1055/s-2008-1052365.
Five children presented with focal seizures and neurological deficits that progressed over a span of months to years. Three had temporal lobectomy to control seizures, one underwent temporal lobe biopsy, and the fifth, who suffered from immunodeficiency, had an occipital lobectomy to remove a mass. Two of the children expired. Neuropathological findings in all five children were consistent with a persistent active "viral" encephalitis. No infectious agent was identified. None of the children had the usual systemic signs of encephalitis and all lacked an inflammatory response in their cerebrospinal fluid. We conjecture that this condition may be more frequent than realized. Besides causing intractable focal seizures and hemiparesis, it may account for other poorly understood syndromes of childhood with deteriorating behavior.
五名儿童出现局灶性癫痫发作和神经功能缺损，这些症状在数月至数年的时间里逐渐发展。其中三名儿童接受了颞叶切除术以控制癫痫发作，一名接受了颞叶活检，第五名患有免疫缺陷，接受了枕叶切除术以切除一个肿块。两名儿童死亡。所有五名儿童的神经病理学检查结果均与持续性活动性“病毒性”脑炎一致。未发现感染病原体。所有儿童均无常见的脑炎全身症状，且脑脊液中均缺乏炎症反应。我们推测这种情况可能比我们意识到的更为常见。除了导致难治性局灶性癫痫发作和偏瘫外，它可能还与其他行为逐渐恶化但难以理解的儿童综合征有关。
