Caires D, Arocha-Pinango C L, Rodriguez S, Linares J
Acta Obstet Gynecol Scand. 1984;63(5):411-6. doi: 10.3109/00016348409156694.
Factor VIIIR:Ag and Factor VIII:C levels were found to be significantly increased during pregnancy, labor and puerperium, but not to the extent observed by European and American authors. The ratio Factor VIIIR:Ag/Factor VIII:C was elevated only between the third and sixth hour of labor with respect to early labor, and during parturition and early puerperium with respect to late labor. However, this ratio was in the same range as the normal non-pregnant controls, but in the cases of complicated pregnancy, the ratio reached values much higher than the normal. It was concluded that determination of the ratio appears to be of little value in normal cases but may be of use when there are obstetrical complications. Studies are being performed to try to explain the limited rise in Factor VIII:Ag and Factor VIII:C levels observed in our cases.
研究发现，妊娠、分娩及产褥期的Ⅷ因子相关抗原（Factor VIIIR:Ag）和Ⅷ因子活性（Factor VIII:C）水平显著升高，但升高程度不及欧美作者所观察到的。Ⅷ因子相关抗原/Ⅷ因子活性比值仅在分娩第3至6小时相对于分娩早期升高，以及在分娩期和产褥早期相对于分娩后期升高。然而，该比值与正常非妊娠对照组处于同一范围，但在妊娠合并症的情况下，该比值远高于正常水平。结论是，在正常情况下，测定该比值似乎价值不大，但在存在产科并发症时可能有用。目前正在进行研究，试图解释我们所观察到的病例中Ⅷ因子抗原和Ⅷ因子活性水平有限升高的原因。
