Bourke D L, Rosenberg M, Allen P D
Anesthesiology. 1984 Nov;61(5):523-8.
Each of six healthy volunteers was studied on three different occasions to determine the interactions of placebo-physostigmine, diazepam-physostigmine, and morphine-physostigmine with respect to respiration and psychomotor function. Respiratory measurements were made using the steady state and isohypercapnic techniques. Psychomotor function was assessed by the Trieger Dot Test (TDT) and compared with the Continuous Performance Test (CPT). Administration of physostigmine alone (3 mg, iv) did not affect ventilation. Diazepam (0.29 mg/kg, iv) did not cause a significant depression of ventilation in all subjects, although psychomotor function was impaired as measured by the CPT. The latter was unaffected by physostigmine. Administration of morphine (0.21 mg/kg, iv) caused a significant decrease in ventilation that was not antagonized by physostigmine. Morphine did not impair psychomotor function. The authors conclude that physostigmine is an ineffective antagonist of narcotic-induced respiratory depression and that the CPT correlates well with the TDT.
六名健康志愿者每人在三种不同情况下接受研究，以确定安慰剂-毒扁豆碱、地西泮-毒扁豆碱和吗啡-毒扁豆碱在呼吸和精神运动功能方面的相互作用。呼吸测量采用稳态和等碳酸血症技术。精神运动功能通过特里格点试验（TDT）进行评估，并与连续性能测试（CPT）进行比较。单独静脉注射毒扁豆碱（3毫克）不影响通气。静脉注射地西泮（0.29毫克/千克）在所有受试者中均未导致通气显著降低，尽管通过CPT测量精神运动功能受到损害。后者不受毒扁豆碱影响。静脉注射吗啡（0.21毫克/千克）导致通气显著下降，毒扁豆碱不能拮抗这种下降。吗啡不损害精神运动功能。作者得出结论，毒扁豆碱是麻醉诱导的呼吸抑制的无效拮抗剂，并且CPT与TDT相关性良好。
