[Blood bunaphthine during dynamic physical exercise and anti-arrhythmic action].

The course of bunaphtinemia during submaximal exercise was studied. To 5 patients showing the appearance or the increase of extrasystole, both ventricular and supraventricular, during ergometric test on the bicycle ergometer, bunaphtine was administered by the following method: a first dose of 0.5 mg/kg was injected endovenously in 2 minutes followed by a constant endovenous infusion at the speed of 2.5 mg/min, throughout the exercise. Doses were calculated referring to a pharmacocynetic pattern with two compartments and supposing an apparent distribution volume of 3 l/k. Resulting bunaphtinemia curves showed a steady state and were completely above the minimum effective standard throughout the test. In all patients the drug prevented ventricular arrhythmias and compared to the standard reduced the supraventricular arrhythmias by 80%.