Fitchett D H
Cardiovasc Res. 1984 Nov;18(11):651-6. doi: 10.1093/cvr/18.11.651.
This study has investigated the origin of the pulsatile expansion of the forearm recorded by the amplification of the pulsatile signal derived from a mercury in rubber plethysmograph. Venous occlusion to pressures of 40 mmHg had no effect on the amplitude of the volume pulse, suggesting that the volume pulse originates in vessels distended by pressures above this level. Nitroglycerin in small doses (0.15 mg sublingual) increased the amplitude of the volume pulse without changing forearm vascular resistance, consistent with an arterial origin of the forearm volume pulse. The instantaneous relationship between the volume pulse and arterial pressure (forearm compliance) showed that nitroglycerin increased the volume pulse in association with a reduction in pulse pressure. As the volume pulse probably originates in the arterial system, the increase in forearm compliance is a measure of the increase in arterial compliance induced by nitroglycerin. Both the volume pulse and forearm compliance may be useful indicators of the effect of physiological and pharmacological interventions on the distensile properties of arteries.
本研究通过对源自橡胶汞柱式体积描记器的搏动信号进行放大，探究了记录到的前臂搏动性扩张的起源。将静脉阻塞至40 mmHg的压力对容积脉搏的幅度没有影响，这表明容积脉搏起源于压力高于该水平而扩张的血管。小剂量硝酸甘油（舌下含服0.15 mg）增加了容积脉搏的幅度，而未改变前臂血管阻力，这与前臂容积脉搏起源于动脉一致。容积脉搏与动脉压之间的瞬时关系（前臂顺应性）表明，硝酸甘油增加了容积脉搏，同时脉压降低。由于容积脉搏可能起源于动脉系统，前臂顺应性的增加是硝酸甘油引起的动脉顺应性增加的一种度量。容积脉搏和前臂顺应性都可能是生理和药理干预对动脉扩张特性影响的有用指标。
