Khatim M S, Al-Mahmood H A, Gumaa K A
FEBS Lett. 1984 Nov 5;177(1):135-7. doi: 10.1016/0014-5793(84)80997-7.
Glibenclamide significantly stimulated the incorporation of [3H]thymidine into DNA of fetal rat pancreatic islets at a physiological (5.5 mM) but not at a high (22 mM) glucose concentration. There was no significant stimulation of insulin release under these conditions. In contrast, the drug-stimulated insulin release from adult islets cultured at 5.5 mM glucose but had no effect on their DNA synthesis. The observations suggest that insulin secretion and DNA synthesis may be dissociated in rat pancreatic islets.
在生理浓度（5.5 mM）葡萄糖条件下，格列本脲能显著刺激[3H]胸腺嘧啶核苷掺入胎鼠胰岛DNA，但在高浓度（22 mM）葡萄糖条件下则无此作用。在这些条件下，胰岛素释放未受到显著刺激。相比之下，该药物能刺激在5.5 mM葡萄糖条件下培养的成年胰岛释放胰岛素，但对其DNA合成无影响。这些观察结果表明，大鼠胰岛中的胰岛素分泌和DNA合成可能是分离的。
