Leuchter R S, Townsend D E, Hacker N F, Pretorius R G, Lagasse L D, Wade M E
Gynecol Oncol. 1984 Nov;19(3):314-22. doi: 10.1016/0090-8258(84)90198-7.
Between January 1960 and December 1982, 142 patients with carcinoma in situ of the vulva were treated at Cedars-Sinai Medical Center and UCLA Medical Center. Primary treatment consisted of wide excision in 45 patients; vulvectomy in 23 patients; topical chemotherapy in 9 patients; and CO2 laser therapy in 42 patients. Twenty-three patients were also treated with the CO2 laser for recurrent disease. Multifocal disease was present in 59% of the cases. Lesions involving the posterior vulva recurred most commonly, for both initial and recurrent disease. Results utilizing the CO2 are compared with the other methods of treating carcinoma in situ of the vulva. The CO2 laser is well suited for treatment of both multifocal and unifocal vulvar lesions, as it allows for maximal retention of vulvar integrity with no decrease in therapeutic efficacy.
1960年1月至1982年12月期间，142例外阴原位癌患者在雪松西奈医疗中心和加州大学洛杉矶分校医疗中心接受了治疗。主要治疗方法包括：45例患者接受了广泛切除术；23例患者接受了外阴切除术；9例患者接受了局部化疗；42例患者接受了二氧化碳激光治疗。23例复发性疾病患者也接受了二氧化碳激光治疗。59%的病例存在多灶性疾病。无论是初始疾病还是复发性疾病，累及外阴后部的病变最常复发。将二氧化碳激光治疗的结果与治疗外阴原位癌的其他方法进行了比较。二氧化碳激光非常适合治疗多灶性和单灶性外阴病变，因为它能最大程度地保留外阴完整性，且治疗效果不降低。
