Usui S, Sakamoto A, Yamazaki K, Tokumoto N, Shu S, Kawamura I, Ryu M, Odaka M, Sato H, Ogoshi S
Nihon Geka Gakkai Zasshi. 1984 Sep;85(9):985-9.
Nutritional management for the patients with cirrhosis after hepatectomy was studied. Based on the experimental results, 1-1.5g/kg/day of branched chain amino acid (BCAA) enriched solution with 30 kcal/kg/day of glucone was given to the cirrhotic patients after hepatectomy for 10-14 days. Sodium and total fluid volume were strictly restricted. Elemental diet for liver failure (ED-H) was started to give within 7 days after surgery for 6-21 days. High relationships were observed between preoperative nutritional status such as prealbumin and retinol binding protein (RBP) and incidence of postoperative complications, suggesting that postoperative nutritional supply was very important. Changes of albumin, hepaplastin test and prothrombin time were rather good and the BCAA to aromatic amino acids molar ratio was maintained high when nutritional management was performed. Overall one and two year survival rates were 74% (20/27) and 36% (5/14), respectively. No significant difference was seen between the prognoses of the patients with and without liver dysfunction. Immediate postoperative nutritional management must be essential to get over critical stage safely and long-term nutritional supply may be necessary to get better prognosis.
对肝切除术后肝硬化患者的营养管理进行了研究。根据实验结果,对肝切除术后的肝硬化患者给予1-1.5克/千克/天富含支链氨基酸(BCAA)的溶液,并搭配30千卡/千克/天的糖异生物质,持续10-14天。严格限制钠和总液体量。在术后7天内开始给予肝功能衰竭要素饮食(ED-H),持续6-21天。观察到术前营养状况如前白蛋白和视黄醇结合蛋白(RBP)与术后并发症发生率之间存在高度相关性,这表明术后营养供应非常重要。当进行营养管理时,白蛋白、肝促凝血酶原激酶试验和凝血酶原时间的变化相当良好,且支链氨基酸与芳香族氨基酸的摩尔比保持较高水平。总体1年和2年生存率分别为74%(20/27)和36%(5/14)。肝功能正常和肝功能异常患者的预后无显著差异。术后立即进行营养管理对于安全度过关键期必不可少,长期营养供应可能对获得更好的预后是必要的。