酸化后肝素化血浆中血小板聚集活性的出现——这主要是由于纤维蛋白原的聚集。
Appearance of platelet-clumping activity in heparinized plasma after acidification--it's mainly due to aggregation of fibrinogen.
作者信息
Yamamoto N, Tanoue K, Yamazaki H
出版信息
Thromb Res. 1984 Oct 15;36(2):103-12. doi: 10.1016/0049-3848(84)90332-3.
Platelet-clumping activity was found after acidifying heparinized rabbit plasma to pH 5.5 in the presence of calcium ions. We tried to isolate the activity from plasma by gel filtration under low salt and high salt condition, and we found that the activity was related to the formation of plasma protein aggregates. Immunological examination and the results of fibrin monomer affinity chromatography indicated that fibrinogen was the main component of the plasma aggregates. This phenomenon was not related to the activation of blood coagulation. The binding of fibrinogen in the presence of heparin or calcium ions at low ionic strength may induce the appearance of platelet-clumping activity.
在钙离子存在的情况下，将肝素化兔血浆酸化至pH 5.5后发现了血小板聚集活性。我们试图在低盐和高盐条件下通过凝胶过滤从血浆中分离该活性，并且发现该活性与血浆蛋白聚集体的形成有关。免疫学检查和纤维蛋白单体亲和层析结果表明，纤维蛋白原是血浆聚集体的主要成分。这种现象与血液凝固的激活无关。在低离子强度下，肝素或钙离子存在时纤维蛋白原的结合可能会诱导血小板聚集活性的出现。
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